Ankylosing Spondylitis: A Type of Spinal Inflammatory Arthritis

Ankylosing spondylitis (AS) is a chronic inflammatory spinal disease characterized by joint pain and progressive stiffness in the cervical (neck), thoracic (mid-back), lumbar (low back), and sacroiliac joints (sacrum). AS is also known as radiographic axial spondyloarthritis.

AS is categorized by enthesopathy, which means an inflammatory attack where tendons and ligaments attach to bones or joint capsules (called enthesis). In the spine, the primary site for this enthesis is where the long spinal ligament (anterior longitudinal ligament) attaches to the front of the vertebrae. Inflammation of the enthesis is called enthesitis.

The onset of AS is usually seen in people ages 15 to 45 years. Early symptoms may be similar to arthritis; low back and buttock pain and stiffness that are worse in the morning and night. Some patients experience loss of appetite and mild fevers.

healthy spine compared to ankylosing spondylitisThe onset of AS is usually seen in people ages 15 to 45 years. Early symptoms may be similar to arthritis. Photo Source:

Progression of Ankylosing Spondylitis

Over months or years, pain may spread up the spine and into the neck. As the disease progresses, the body's defense mechanisms fight back by producing new bone (ossification). The new bone grows between and around the vertebrae, causing abnormal fusion and increases the risk for spinal fracture.

Sometimes ankylosing spondylitis leads to a spinal deformity such as a humpback (abnormal kyphosis) or swayback (abnormal lordosis). Advanced symptoms can be chronic and include severe pain and stiffness of the spine and possibly other body joints. Bowel (Chrohn's disease) and eye inflammation (iritis, uveitis) may be associated with ankylosing spondylitis.

Ankylosing Spondylitis Treatment May Include:

  • Medications
    As with more common osteoarthritis, treatment often begins with non-steroidal anti-inflammatory medications (eg, naproxen). Although most patients' symptoms respond well to anti-inflammatory medication, these drugs do not treat the underlying disease. Sometimes medications are not strong enough.

    Unlike osteoarthritis, in inflammatory arthritis, certain medications can affect the actual disease. For example, TNF-blocking drugs may help block a protein that can cause inflammation (Tumor Necrosis Factor). Adalimumab (Humira), etanercept (Enbrel) and ixekizumab (Taltz) are three types of TNF-blockers that may stop disease progression.
  • Physical therapy, therapeutic exercise
    Physical therapy stresses proper posture, joint mobility, and deep breathing. Some patients may develop forward posture; therefore, postural training and extension exercise is helpful. Stretching and range of motion exercise helps keep the facet and rib joints mobile. Additionally, deep breathing expands the chest (rib joints) and aids lung function.

Spinal Inflammatory Arthritis Glossary

Updated on: 12/10/19
Continue Reading
Ankylosing Spondylitis: Description and Diagnosis
Continue Reading:

Ankylosing Spondylitis: Description and Diagnosis

Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis condition that can affect the spine. Spine expert-written article on ankylosing spondylitis and how it's diagnosed.
Read More